Selenium and vitamin E are both involved in protecting cells against free radicals that cause cellular damage. Selenium contributes to the destruction of oxidizing components, while vitamin E prevents their formation and often a deficiency in one leads to an increased requirement for the other. Therefore, vitamin E and Se have a lot of similarities in building an effective antioxidant defence network in the body. Both vitamin E and Se are important elements for the redox balance regulation and this could be related to the maintenance of the antioxidant defence, immunity system, gut health, reproduction, growth and development of livestock in commercially relevant stress conditions.